Generations of studying the root cause of schizophrenia have largely converged around a single theory: the “dopamine hypothesis,” which postulates that a combination of genetic susceptibility, ...

Mice were bred in the Department of Comparative Medicine animal facility at the New York State Psychiatric Institute (NYSPI) at the Columbia University Medical Center. The floxed tetO1B mouse model ...

Autoreceptors have an important role in neuronal homeostasis by regulating presynaptic functions in a feedback-inhibitory manner. There are three manifestations of autoreceptor function, reflecting ...

PITTSBURGH, Oct. 1 – Although drugs that target the brain's serotonin system are widely used to treat depression, the basic biological mechanism by which they help to alleviate symptoms is poorly ...

The caudate nucleus (green) is a subcortical brain region located in the striatum. The striatum is one of several neural structures that make up the basal ganglia (colored regions) located below the ...