BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...

Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation 1 and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater ...

Viruses cannot replicate by themselves. Instead, they rely on the host for almost all their replicative functions. Similarly, many viruses are unable to cause damage without the host immune system.

Skin wounds from ischemia-reperfusion injuries -- tissue damage caused by blood returning to tissues after a period of oxygen deprivation -- may not heal appropriately in some patients, owing to ...

We just recently published our definition, the National Psoriasis Foundation's, definition of remission for psoriasis, and it ...

Accurate measurement of HMGB-1, neopterin and sIL-2R supports reliable assessment of immune activation across clinical and ...

The results of the MIROCALS randomized clinical trial have shown that adding low-dose interleukin-2 (IL2LD) to standard treatment for amyotrophic lateral sclerosis slowed functional decline and ...

Adjuvant High-Dose Bolus Interleukin-2 for Patients With High-Risk Renal Cell Carcinoma: A Cytokine Working Group Randomized Trial Purpose: This three-arm randomized study compares response rates and ...

Interleukin-6 (IL-6) is a pleiotropic cytokine that may play a role in the regulation of various aspects of the immune response, inflammation, hematopoiesis, and bone metabolism. IL-6 acts by binding ...